The actual message of your email is most important. What point are you getting across? What key information are you trying to share? You can dress up a message all you want, but if your main point is unclear, then you have simply wasted your time and your readers' time. Focus on what you're actually saying, before the fluff.
Make sure to address people the way they want to be addressed. If someone signs their email as "Chris", you should reply "Dear Chris". If they sign with "Dr. Nelson", you should reply "Dear Dr. Nelson,"
Try to avoid generic greetings, especially ones that don't sound like a real person. You may write "Good afternoon!" as a greeting, but a native English speaker is unlikely to write "Dear kind sirs/madams:"
Your email greeting should sound like you really care about the person you are emailing with.
You shouldn't be telling someone "Happy Holidays" in your signature when it's already January. Make sure your email footer is up to date. Nothing can kill a company's professional look than an out of date signature.
You should consider making your signature unique. Pick a final greeting that's more than just "Sincerely" - although many people have started to do the same, and it starts to appear disingenuous. What's better is a signature that matches your brand!
If you sell surfboards, "Surfs up dude," is a great end greeting. Think of what might fit your brand and show it off!